منابع مشابه
Molecular mechanisms of general anesthesia
General anesthetics produce a widespread neurodepression in the central nervous system by enhancing inhibitory neurotransmission and reducing excitatory neurotransmission. However, the action mechanisms of general anesthetics are not completely understood. Moreover, the general anesthetic state comprises multiple components (amnesia, unconsciousness, analgesia, and immobility), each of which is...
متن کاملMechanisms of general anesthesia.
Although general anesthetics are often said to be nonspecific agents, it is likely that they act at a much more restricted set of target sites than commonly believed. The traditional view has been that the primary targets are lipid portions of nerve membranes, but recent evidence shows that the effects on lipid bilayers of clinically relevant levels of anesthetics are very small. Effects on mos...
متن کاملCerebral mechanisms of general anesthesia.
How does general anesthesia (GA) work? Anesthetics are pharmacological agents that target specific central nervous system receptors. Once they bind to their brain receptors, anesthetics modulate remote brain areas and end up interfering with global neuronal networks, leading to a controlled and reversible loss of consciousness. This remarkable manipulation of consciousness allows millions of pe...
متن کاملThe expanding genetic toolkit for exploring mechanisms of general anesthesia.
769 April 2013 S ERIOUS scientific efforts aimed at understanding how general anesthetics produce their powerful effects began soon after the historic demonstration of ether anesthesia on October 16, 1846 in Boston, Massachusetts. Progress was slow for most of the intervening 166 years, but has dramatically advanced during the last three decades, aided by new ideas and the revolutionary techniq...
متن کاملStunning the neural nexus: mechanisms of general anesthesia.
General anesthesia requires managing a complex array of anesthetic agents that act on an intricate web of neural connections or neural nexus. Both inhaled and intravenous anesthetics must intervene at some level of the neural nexus that provides for amnesia, immobility, hypnosis, and suppression of noxious reflexes. These interactions occur at the spinal and supraspinal level and involve spinal...
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ژورنال
عنوان ژورنال: Korean Journal of Anesthesiology
سال: 2010
ISSN: 2005-6419,2005-7563
DOI: 10.4097/kjae.2010.59.1.3